(...)
What is the luck of the sperm but a series of correct choices? Like species intelligence is a series of correct choices. And individual intelligence is reason with action; choice.
Isolating chemicals isolates the man using them. Depending on the sophistication of the process as the base, and the number of times processed, it could be 1 in (2,4,8...) or 1 in (10,100,1000...) likely to have a synergistic/symbiotic/synchronistic(getting back to luck) effect.
Most of you aren't considering that the isolate isn't just the apparently useful part of the plant. They are further refined with more select action the more it's processed ie. opium > morphine > heroin > codeine in order of refinement, not to mention more synthetic options like fentanyl and bupronorphine. Then there's ephedra > amphetamine (speed) > methamphetamine. It's like having less and less useful DNA in junk DNA.