Well, my new challenge character that I made to bust out of my base/hoarding gameplay slump has been very interesting so far. The rules I set for myself were just: a) No creating stashes, and b) No sleeping more than one night in a given building, ever. Having to rely on only what you can carry certainly makes for more interesting decisions. I also turned on IntCap skill rust as opposed to leaving it off altogether.
The most fun part has actually been rather unexpected. I actually intended to make this guy
not mutation-based for once, so decided to forego Robust Genetics. Right out of the shelter, though, I found some dead scientists with a mutagen, which I knocked back and scored... Unstable Genetics. So my wanderer has been slowly but inevitably turning into some kind of...cow? With fangs, apparently. He's gained 5 strength and hooves and just recently sprouted moose antlers.
I'm really enjoying it from a sort of RP perspective. It's one thing intentionally mutating yourself, but another thing altogether to be constantly mutating out of your control. He's found and used a couple purifiers, which took the edge off some of the nastier things (lost light sensitive and, temporarily, ponderous) but without losing Unstable Genetics the poor guy's in a losing battle for his humanity. I've finally located a lab on the other side of the town to tackle as a mid-term goal to hunt for more purifiers.
Should also mention that I found a Nodachi in somebody's basement, so my unintentional minotaur-in-training is clopping around with a trenchcoat and giant katana. While wearing slightly cracked sunglasses. Real cool until you remember the moose antlers.
I enjoy this game.