This has been mentioned before, and there some third party mods that let you do some of this, however I think it is worth mentioning again and again. The manager dwarf is almost worthless and I think job priorities would streamline my experience with the game a great deal.
I've found the manager dwarf to be absolutely essential in DF 2010...much easier to queue up a batch of 30 smelt-ore or make-charcoal/coke tasks (as well as cranking out clothing) that way. I find it much easier to specify production orders that way, especially for equipment used by the military (not to mention the wonderfully Soviet feel of a centrally planned economy). For crafts, though, I manage those myself to keep the workshops from being shut down because there's only one dwarf that can make leather crafts and the job order has been spread across multiple workshops.
That being said, I'd like to see prioritization for jobs...at a minimum, hauling at the bottom (except food). In 2010, I've noticed a lot better prioritization of tasks (e.g. my broker going to the depot quickly without turning off his labors), but it still leaves much to be desired.