Depends on what you mean by mathematical notation, but most spreadsheet programs I'm aware of can manage one way or another. Personally have found it pretty helpful over the years, since setting up anything particularly complicated with functions and whatnot means you both have to be able to break your problem down to its component parts and you can subsequently trivially see what happens when you fiddle with the numbers. S'good stuff.
Pretty sure there's more specialized software out there, too. Field of mathematics is way too big and way too intertwined with software development for there not to be, really.
... still no answer for what hand of skill actually means, though. I'm not voting until I know what I'm voting on